January 20 2021
Glutathione (GSH) has generated waves of activity raging through different scientific fields. Currently, we are in one such wave, related to the role of thiols in gene expression, apoptosis, signaling, etc. There are well over 40,000 entries under “glutathione” found at the Medline database, reflecting the importance of this biomolecule. In the following, the field is highlighted, with the hope of conveying a feel for where future developments may go.
The tripeptide, L-g-glutamyl-L-cysteinyl-glycine, or GSH is the major low-molecular-mass thiol compound in plants and animals. In cells, tissues, and plasma, glutathione is present in several additional forms. Glutathione disulfide (GSSG), is formed upon oxidation; sometimes, this species is referred to as “oxidized glutathione,” but further oxidation products are also formed from GSH. GSH is synthesized from L-glutamate, L-cysteine, and glycine in two consecutive steps, catalyzed by g-glutamyl-cysteine synthase and glutathione synthase.
WHAT DOES IT DO IN YOUR BODY?
Glutathione is involved in the detoxification of both xenobiotic and endogenous compounds. It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralizes (POPs, many oxidative chemicals). Glutathione facilitates the plasma membrane transport of toxins by at least 4 different mechanisms, the most important of which is formation of glutathione S-conjugates. Low levels of glutathione and/or transferase activity are also associated with chronic exposure to chemical toxins and alcohol, cadmium exposure, AIDS/HIV, macular degeneration, Parkinson’s disease, and other neurodegenerative disorders.
Glutathione directly scavenges diverse oxidants: superoxide anion, hydroxyl radical, nitric oxide, and carbon radicals. Glutathione catalytically detoxifies: hydroperoxides, peroxynitrites, and lipid peroxides.
DISEASES ASSOCIATED WITH GLUTATHIONE DEPLETION
- Neurodegenerative disorders (Alzheimer’s, Parkinson’s, and Huntington’s diseases, amyotrophic lateral sclerosis, Friedreich’s ataxia)
- Pulmonary disease (COPD, asthma, and acute respiratory distress syndrome)
- Immune diseases (HIV, autoimmune disease)
- Cardiovascular diseases (hypertension, myocardial infarction, cholesterol oxidation)
- Chronic age-related diseases (cataracts, macular degeneration, hearing impairment, and glaucoma)
- Liver disease
- Cystic fibrosis
- Aging process itself
HOW THIS PRODUCT CAB BE USEFUL
For skin lightening: Glutathione indirectly inhibits tyrosinase enzyme responsible for melanin production leads to light skin tone. Glutathione not only decreases the melanin (pigmentation) in your skin, but has also been found to decrease wrinkles and increase skin elasticity.
Improves immune system: Glutathione helps your immune system stay strong and ready to fight infections. Glutathione (GSH) primes white cells such as natural killer (NK) and T cells, your body’s front-line infection fighters. GSH-enhanced T cells are able to produce more infection-fighting substances, controlling both bacterial and viral infections.
Detoxification: Glutathione is involved in the detoxification of both xenobiotic and endogenous compounds. It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralizes (POPs, many oxidative chemicals). Glutathione directly scavenges diverse oxidants: superoxide anion, hydroxyl radical, nitric oxide, and carbon radicals
Improves energy production: Energy production occurs within all cells (except red blood cells) via the mitochondria. Glutathione protects mitochondria from free radicals and the oxidative damage they cause. In this way, glutathione is paramount to energy production.
Prevents cardiovascular diseases: Virtually all heart disease starts with the accumulation of arterial plaque inside the artery walls. Bad cholesterol (LDL) is lipid oxidized and damages the lining of the blood vessels, forming a plaque (atherosclerosis). With the help of an enzyme called glutathione peroxidase, glutathione stops the superoxides, free radicals, hydrogen peroxides, lipid peroxides, and peroxynitrites that cause this lipid oxidation and wreak havoc on your health.